Upon pickup, Upgrade 1 of your Strikes and 1 of your Defends.
Neow’s Talisman currently ranks #250 out of 292 in the Slay the Spire 2 Relics tier list with a rating of 1417.68.
This ranking is based on 38 community votes (12 wins, 26 losses) for a win rate of 31.6%.