Upon pickup, Upgrade 1 of your Strikes and 1 of your Defends.
Neow’s Talisman currently ranks #248 out of 292 in the Slay the Spire 2 Relics tier list with a rating of 1419.05.
This ranking is based on 40 community votes (13 wins, 27 losses) for a win rate of 32.5%.